Description

RIODINE SOLN is a versatile pharmaceutical solution designed for various administration routes, including oral and injectable forms. Its primary active ingredient, known as compound (1), is available in multiple crystalline forms, with Form B being the most stable. This stability is characterized by specific X-ray powder diffraction peaks and thermal properties, ensuring consistent performance.

Crystalline and Amorphous Forms

• Crystalline Forms: The product's crystalline forms can be anhydrous or hydrated, influencing its formulation and application.
• Amorphous Salts: These are available as acid addition salts, suitable for oral or inhalation administration, with particle sizes tailored through techniques like micronization and spray drying.

Formulation Techniques

The synthesis of compound (1) involves precise amide-bond forming reactions, utilizing specific coupling agents and solvents. This meticulous process contributes to the product's efficacy and reliability.

Oral Administration

For oral use, RIODINE SOLN can be formulated as a solution or suspension using vehicles such as ethanol and propylene glycol. Surfactants are included to enhance solubility and prevent precipitation in the gastrointestinal tract. The concentration of compound (1) ranges from 10 to 130 mg/ml, allowing flexible dosing options. It may also be encapsulated in gelatin or non-gelatin capsules.

Injectable Formulations

Injectable solutions are prepared for intravenous, subcutaneous, or intramuscular administration. These formulations may include excipients like propylene glycol and acetate buffer, with sterilization achieved through filtration or autoclaving. Additionally, lyophilized forms are available, requiring reconstitution with suitable diluents for intravenous use.

Key Benefits

• Solubility Management: Due to poor water solubility, RIODINE SOLN employs non-aqueous vehicles and surfactants to enhance bioavailability.
• Versatile Administration: Suitable for various administration routes, tailored to specific therapeutic needs.
• Advanced Formulation: Utilizes cutting-edge techniques in particle size reduction and formulation to optimize delivery and efficacy.

RIODINE SOLN exemplifies advanced pharmaceutical engineering, offering a robust solution for healthcare professionals seeking reliable and adaptable medication options.