Description

Thiopental Sodium, marketed under the name LABEL THIOPENTONE, is a specialized pharmaceutical product designed for intravenous administration. This product is a hygroscopic powder, ranging in color from yellowish to white, and is intended for reconstitution into a solution for injection. It is primarily used as a rapid-onset, short-acting barbiturate general anesthetic and hypnotic.

Key Features

• Active Ingredient: Thiopental Sodium
• Intended Use: Induction of anesthesia and management of convulsive states
• Applications: Suitable for both human and veterinary medicine

Packaging and Dosage

LABEL THIOPENTONE is supplied in glass vials with varying quantities of 0.5 g, 470 mg, or 1 g of thiopental sodium. These vials are available in packs containing 1, 10, 25, 50, or 100 units. The product is reconstituted with sterile water, 0.9% sodium chloride, or 5% dextrose to achieve desired concentrations for intravenous use.

Administration

The administration of this product is strictly intravenous and should be conducted by trained professionals. Dosage is individualized based on factors such as age, weight, and clinical condition. The onset of action occurs within 30 to 45 seconds, with effects lasting between 5 to 15 minutes.

Pharmacological Properties

Thiopental Sodium acts as a central nervous system depressant, interacting with GABA-A receptors to prolong receptor opening and depress synaptic transmission. It is highly lipophilic, allowing rapid penetration of the blood-brain barrier. The product is metabolized in the liver and primarily eliminated through urine.

Contraindications and Precautions

Use of LABEL THIOPENTONE is contraindicated in individuals with hypersensitivity to barbiturates, certain respiratory and cardiac conditions, and other specific medical conditions. It is crucial that it is administered in settings equipped for airway and cardiovascular support, with appropriate resuscitation equipment available.

Storage Instructions

The powder should be stored below 25°C in its original, tamper-proof container. Once reconstituted, the solution should be stored in a refrigerator for up to 24 hours or at room temperature for up to 6 hours. Proper disposal of unused portions and containers is essential, adhering to regulations for drugs of addiction.

Safety Measures

Handling of the product requires personal protective equipment such as goggles, gloves, and protective clothing. In case of exposure, immediate first aid measures include washing affected areas with water and seeking medical attention if necessary.

LABEL THIOPENTONE is a controlled substance, registered with the Australian Register of Therapeutic Goods, and is classified as a Schedule 4 prescription-only medicine in Australia.