Description

HYALASE AMP is a specialized pharmaceutical product designed to enhance the effectiveness of subcutaneous or intramuscular injections and infusions. Each ampoule contains 1,500 international units of hyaluronidase, presented as a sterile, freeze-dried powder. This formulation is intended for healthcare professionals seeking to improve the permeation and absorption of fluids or medications in various medical contexts.

Formulation and Packaging

• Appearance: The powder is white or pale yellowish white.
• Packaging: Supplied in 1 mL clear glass ampoules.
• Pack Sizes: Available in packs of 1, 5, or 10 ampoules.

Mechanism of Action

Hyaluronidase works by temporarily depolymerizing hyaluronic acid in connective tissue, thereby increasing tissue permeability. This action facilitates the dispersal and absorption of co-administered substances, making it particularly useful in applications such as local anaesthesia, ophthalmology, and the management of excess tissue fluids.

Preparation and Administration

• Preparation: Dissolve the contents of one ampoule in approximately 1 mL of sterile distilled water, normal saline, or the intended injection solution.
• Usage: Intended for immediate use after preparation. Any remaining solution should be discarded.
• Administration: Can be administered via subcutaneous or intramuscular injection, or added to infusion tubing for subcutaneous infusion.

Indications

HYALASE AMP is indicated for:

• Enhancing the absorption of local anaesthetics.
• Promoting the resorption of excess fluids and blood in tissues.
• Aiding in the subcutaneous administration of radiopaque substances.

Contraindications and Precautions

Use of HYALASE AMP is contraindicated in individuals with hypersensitivity to hyaluronidase, at sites of infection or malignancy, and in specific drug interactions. It should not be administered intravenously or used to enhance the absorption of certain substances such as dopamine or alpha agonists.

Adverse Effects

Potential adverse effects include local reactions such as oedema, irritation, or allergic responses. In rare cases, severe allergic reactions may occur. When used in eye surgery, it may cause visual disturbances or eye swelling.

Storage Instructions

• Temperature: Store below 25°C.
• Packaging: Keep in original packaging until use.
• Shelf Life: Unopened shelf life of 3 years.

Legal Status

HYALASE AMP is generally classified as a prescription-only medication, with specific scheduling varying by jurisdiction. Healthcare professionals should consult relevant guidelines to ensure appropriate use and handling.