Description

Formalin Solution 10% Neutral Buffered is a widely recognized chemical solution essential in histology and laboratory settings. Its primary role is to serve as a universal fixative for biological tissue specimens, making it invaluable in research, clinical, and educational laboratories.

Key Features

• Neutral pH Balance: Buffered to a neutral pH of approximately 7.0 using phosphate salts, this solution minimizes tissue artefacts, ensuring the preservation of tissue morphology during fixation.
• Effective Preservation: Prevents autolysis and bacterial decomposition, maintaining both nuclear and cytoplasmic structures for clear microscopic examination.
• Compatibility: Works well with a wide range of downstream processing techniques, including dehydration, embedding, sectioning, staining, immunohistochemistry, and various molecular methods.

Composition

• Formalin Content: Comprises 10% formalin, equivalent to 3.7–4% formaldehyde by weight/volume.
• Buffering Agents: Includes phosphate salts, with water as the solvent, and may contain a small amount of methanol as a stabilizer.

Handling and Storage

• Storage Conditions: Should be stored at room temperature in a tightly closed, clearly labeled container.
• Safety Measures: Appropriate personal protective equipment (PPE) is recommended during handling. Ensure disposal aligns with local regulations.

Safety Information

• Hazard Classification: Known to cause skin and eye irritation and allergic reactions due to the formaldehyde component. It is also classified as a carcinogen.
• Environmental Precautions: Toxic to aquatic life; avoid releasing into waterways. Handle in a well-ventilated area to prevent inhalation or ingestion.

This solution's reliable performance and stability under normal laboratory conditions make it a staple for preserving specimens for long-term study, compatible with most histological stains and protocols.