Description

CUSTODIOL-HTK SOLN, developed by Dr. Franz Köhler Chemie GmbH, is a specialized solution designed for the preservation of organs, tissues, and cells during transplantation and cardiac surgery. Its formulation aims to minimize ischemic and reperfusion injury, making it an essential tool in medical procedures requiring temporary organ preservation.

Key Features

• Electrolyte Balance: Maintains crucial electrolyte balance and buffering capacity, supporting metabolic processes during reduced blood supply or hypothermia.
• Low Viscosity: Features low viscosity and low potassium content, reducing the risk of hyperkalemia and arrhythmias.
• Ready-to-Use: Requires no additives or filters, suitable for both abdominal and thoracic organ preservation.

Composition

The solution includes components such as:

• Sodium chloride
• Potassium chloride
• Magnesium chloride
• Calcium chloride
• Histidine
• Mannitol
• Tryptophan

These elements contribute to its high buffering capacity and ability to maintain pH levels, protecting against acidosis.

Mechanism of Action

CUSTODIOL-HTK SOLN works by:

• Moderating pH changes
• Reducing cellular edema
• Supporting aerobic metabolism
• Protecting against oxidative damage

Its low calcium and elevated magnesium levels help reduce cellular injury, while antioxidants provide additional protection.

Administration

This solution is versatile in administration, suitable for use via perfusion, injection, or pump devices. It is typically used for flushing donor organs and is available in various container sizes, including bottles and bags.

Clinical Applications

Ideal for:

• Organ transplantation (heart, kidney, liver, pancreas)
• Cardiac surgery
• Hypothermic storage and transport of organs

CUSTODIOL-HTK SOLN provides reliable protection, reducing inflammation and supporting mitochondrial function during critical medical interventions.

Safety and Handling

With a shelf life of approximately one year, this solution offers safe handling characteristics, allowing direct release into the recipient’s circulation with minimal risk of post-transplant complications. Its design ensures that healthcare professionals can rely on its consistent performance in preserving vital organ functions.