Description

Advil, a well-known nonsteroidal anti-inflammatory drug (NSAID), contains ibuprofen as its active ingredient. It is widely used for the temporary relief of mild to moderate pain, including headaches, backaches, muscle pain, dental pain, and period pain. Additionally, Advil is effective in reducing fever and alleviating symptoms associated with conditions such as osteoarthritis and rheumatoid arthritis.

Dosage Forms

Advil is available in various forms and strengths to suit different needs:

• Tablets: 100 mg to 800 mg
• Capsules: 200 mg, including soft gelatin capsules and Liqui-Gels
• Chewable Tablets: 50 mg and 100 mg
• Oral Suspension: Suitable for children and infants
• Effervescent Tablets and Topical Gel (in some markets)
• Intravenous Solution for specific medical conditions in neonates

Physical Characteristics

Some of the distinct physical characteristics include:

• 200 mg Tablet: Pinkish-brown, sugar-coated, with "Advil" printed on one side
• 200 mg Soft Capsule: Clear, green, oval-shaped
• 400 mg Caplet: Brown, film-coated, capsule-shaped

Administration Guidelines

For adults, the typical oral dosage ranges from 200 to 400 mg every 4 to 6 hours as needed, with specific guidelines for maximum daily intake. Pediatric dosing is based on weight, ensuring safe and effective use. It is recommended to take Advil with food or milk to minimize gastrointestinal effects.

Mechanism of Action

Advil works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the synthesis of prostaglandins involved in pain, inflammation, and fever. This leads to a rapid onset of action, typically within 30 to 60 minutes, providing relief for 4 to 6 hours.

Precautions

Users should be aware of potential risks, including cardiovascular and gastrointestinal adverse events, especially with prolonged use. It is contraindicated in individuals with certain medical conditions, such as significant renal impairment or hypersensitivity to NSAIDs. Special caution is advised for pregnant women, particularly after 30 weeks of gestation.

Common Adverse Effects

Some common side effects include dizziness, nausea, and heartburn. More serious effects, though less common, may include gastrointestinal bleeding and renal impairment. Therefore, it is important to adhere to recommended dosages and consult a healthcare professional if necessary.

Storage Instructions

Advil should be stored below 25°C in a dry place, with child-resistant packaging to ensure safety. Proper disposal of unused or expired medication is advised to prevent accidental ingestion.

Regulatory Information

In Australia, Advil is classified as a Schedule 2 or Schedule 3 medicine, depending on the formulation, making it accessible without a prescription for most forms. This allows for convenient management of common pain and fever symptoms while ensuring responsible use through pharmacist guidance.